ATRX Loss on the X Chromosome: A Key Chromatin Guardian with High Prognostic Impact in Melanoma

Abstract excerpt

<title>Abstract</title> <p>In our study, we investigated the role of the chromatin remodeler ATRX in the progression of cutaneous melanoma. We analyzed ATRX protein expression in over 350 melanomas, correlating findings with clinical data, tumor proliferation rates, and vessel density. Additionally, we examined whole-genome sequencing data from 70 melanoma metastases to assess ATRX genetic alterations and compare...

Topics

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• Biomarkers, Tumor
• Cell Proliferation
• Chromatin
• DNA Copy Number Variations
• Gene Expression Regulation, Neoplastic
• Melanoma
• Skin Neoplasms
• X-linked Nuclear Protein

Identifiers and source

Literature Corpus work

d350399c-d280-593a-a9c4-766e0c6d6ba2

DOI

10.21203/rs.3.rs-6718660/v1