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Article

The chromatin guardian ATRX is a strong prognostic biomarker in melanoma.

Scientific reports - 18 Dec 2025

Frei Céline Arlette, Litchfield Cassandra, Mihic Alanna, Prutek Fabiola, Fitsche André, Wiesmann Fabius, Wanner Miriam, Sobottka Bettina, Mihic-Probst Daniela

Abstract excerpt

In our study, we investigated the role of the chromatin remodeler ATRX in the progression of cutaneous melanoma. We analyzed ATRX protein expression in over 350 melanomas, correlating findings with clinical data, tumor proliferation rates, and vessel density. Additionally, we examined whole-genome sequencing data from 70 melanoma metastases to assess ATRX genetic alterations and compared these with protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA Copy Number Variations

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 41413146
DOI: 10.1038/s41598-025-30842-4
PMCID: PMC12789088

Genes

ATRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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