Article

ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas

2020-10-23

Abstract excerpt

Whole genome and transcriptome sequencing of a cohort of 67 leiomyosarcomas revealed ATRX to be one of the most frequently mutated genes in leiomyosarcomas after TP53 and RB1 . While its function is well described in the alternative lengthening of telomeres mechanism, we wondered whether its alteration could have complementary effects on sarcoma oncogenesis. ATRX alteration is associated with the down-expressi...

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Literature Corpus work: f54d10af-a56b-5a65-9c14-b744982f8ca4
DOI: 10.1101/2020.10.23.352112

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