Genetic Layout of Melanoma Lesions Is Associated with BRAF/MEK-Targeted Therapy Resistance and Transcriptional Profiles.

doi:10.1016/j.jid.2022.04.027

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Article

Genetic Layout of Melanoma Lesions Is Associated with BRAF/MEK-Targeted Therapy Resistance and Transcriptional Profiles.

The Journal of investigative dermatology - 1 Nov 2022

Vergani Elisabetta, Busico Adele, Dugo Matteo, Devecchi Andrea, Valeri Barbara, Cossa Mara, Di Guardo Lorenza, De Cecco Loris, Feltrin Erika, Valle Giorgio, Deho Paola, Frigerio Simona, Lalli Luca, Gallino Gianfrancesco, Del Vecchio Michele, Santinami Mario, Pruneri Giancarlo, Tamborini Elena, Rivoltini Licia, Sensi Marialuisa, Vallacchi Viviana, Rodolfo Monica

Abstract excerpt

The genetic landscape of melanoma resistance to targeted therapy with small molecules inhibiting BRAF and MEK kinases is still largely undefined. In this study, we portrayed in detail the somatic alterations of resistant melanoma and explored the associated biological processes and their integration with transcriptional profiles. By targeted next-generation sequencing and whole-exome sequencing analyses, a list...

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PMID: 35643181
DOI: 10.1016/j.jid.2022.04.027

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