Article

Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

2021-07-14

Abstract excerpt

<h4>Summary</h4> The mammalian target of rapamycin complex 1 (mTORC1) is tightly controlled by tuberous sclerosis complex-2 (TSC2) that is regulated by phosphorylation from kinases responding to environmental cues. Protein kinase G specifically modifies serine-1365 (S1364, human), and its phosphorylation (or phosphomimetic SE mutant) potently blocks mTORC1 co-activation by pathological stress, while a phospho-sil...

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Literature Corpus work: d3451d23-fe1c-53df-bb66-9500d04255bd
DOI: 10.1101/2021.07.13.452249

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