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Article

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.

Nature - 16 Feb 2017

Arif Abul, Terenzi Fulvia, Potdar Alka A, Jia Jie, Sacks Jessica, China Arnab, Halawani Dalia, Vasu Kommireddy, Li Xiaoxia, Brown J Mark, Chen Jie, Kozma Sara C, Thomas George, Fox Paul L

Abstract excerpt

Metabolic pathways that contribute to adiposity and ageing are activated by the mammalian target of rapamycin complex 1 (mTORC1) and p70 ribosomal protein S6 kinase 1 (S6K1) axis. However, known mTORC1-S6K1 targets do not account for observed loss-of-function phenotypes, suggesting that there are additional downstream effectors of this pathway. Here we identify glutamyl-prolyl-tRNA synthetase (EPRS) as an...

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PMID: 28178239
DOI: 10.1038/nature21380
PMCID: PMC5480610

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