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Article

Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth.

Genes & development - 15 Mar 2007

Hietakangas Ville, Cohen Stephen M

Abstract excerpt

Phosphatidylinositol-3-kinase (PI3K)/AKT signaling is essential for growth and metabolism and is elevated in many cancers. Enzymatic activity of AKT has been shown to depend on phosphorylation of two conserved sites by PDK1 and TOR (target of rapamycin) complex 2 (TORC2) in a PI3K-dependent manner. Here we analyze the role of TORC2-mediated AKT phosphorylation in Drosophila. Mutants removing critical TORC2...

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Identifiers

PMID: 17369395
DOI: 10.1101/gad.416307
PMCID: PMC1820936

Genes

PDK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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