Article
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Nature cell biology - 1 Nov 2013
Liu Pengda, Gan Wenjian, Inuzuka Hiroyuki, Lazorchak Adam S, Gao Daming, Arojo Omotooke, Liu Dou, Wan Lixin, Zhai Bo, Yu Yonghao, Yuan Min, Kim Byeong Mo, Shaik Shavali, Menon Suchithra, Gygi Steven P, Lee Tae Ho, Asara John M, Manning Brendan D, Blenis John, Su Bing, Wei Wenyi
Abstract excerpt
The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. Here we report that phosphorylation of Sin1 at Thr 86 and Thr 398 suppresses mTORC2 kinase activity by dissociating...
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