Article
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Nature cell biology - 1 Sept 2002
Inoki Ken, Li Yong, Zhu Tianquan, Wu Jun, Guan Kun-Liang
Abstract excerpt
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 tumour suppressor gene is responsible for both the familial and sporadic forms of this disease. TSC1 and TSC2 proteins form a physical and functional complex in vivo. Here, we show that TSC1-TSC2 inhibits the p70 ribosomal protein S6 kinase 1...
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