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Article

MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury.

Circulation research - 5 Mar 2021

Oeing Christian U, Jun Seungho, Mishra Sumita, Dunkerly-Eyring Brittany L, Chen Anna, Grajeda Maria I, Tahir Usman A, Gerszten Robert E, Paolocci Nazareno, Ranek Mark J, Kass David A

Abstract excerpt

RATIONALE: The mTORC1 (mechanistic target of rapamycin complex-1) controls metabolism and protein homeostasis and is activated following ischemia reperfusion (IR) injury and by ischemic preconditioning (IPC). However, studies vary as to whether this activation is beneficial or detrimental, and its influence on metabolism after IR is little reported. A limitation of prior investigations is their use of broad...

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Identifiers

PMID: 33401933
DOI: 10.1161/CIRCRESAHA.120.317710
PMCID: PMC8257748

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