Article

Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation <i>in vivo</i>

2019-05-15

Abstract excerpt

SWI/SNF complexes regulate transcription through chromatin remodeling and opposing gene silencing by Polycomb-group (PcG) proteins. Genes that encode SWI/SNF subunits are frequently mutated in human cancer. The selective advantage, subunit bias, and common heterozygosity of such mutations remains poorly understood. Here, we characterized how functional loss of various SWI/SNF subunits and PcG EZH2 affect prolifera...

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Literature Corpus work: d32f5e17-8c68-54ea-b149-f52056d4b8e3
DOI: 10.1101/636720

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