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Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores <i>Caenorhabditis elegans</i> development in the absence of SWI/SNF function

2022-09-28

Abstract excerpt

SWItch/Sucrose Non-Fermenting (SWI/SNF) complexes are a family of chromatin remodellers that are conserved across eukaryotes. Mutations in subunits of SWI/SNF cause a multitude of different developmental disorders in humans, most of which have no current treatment options. Here we identify an alanine to valine causing mutation in the SWI/SNF subunit snfc-5 ( SMARCB1 in humans) that prevents embryonic lethality i...

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Identifiers and source

Literature Corpus work
968006a7-0847-5938-9d85-5206b9d0780b
DOI
10.1101/2022.09.27.509717
Open publication

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Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores <i>Caenorhabditis elegans</i> development in the absence of SWI/SNF functionDOI 10.1101/2022.09.27.509717
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