Article

Antagonistic roles of Polycomb repression and Notch signaling in the maintenance of somatic cell fate in <i>C. elegans.</i>

2016-06-02

Abstract excerpt

Reprogramming of somatic cells in intact nematodes allows characterization of cell plasticity determinants, which knowledge is crucial for regenerative cell therapies. By inducing muscle or endoderm transdifferentiation by the ectopic expression of selector transcription factors, we show that cell fate is remarkably robust in fully differentiated larvae. This stability depends on the presence of the Polycomb-assoc...

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Literature Corpus work: 247717a1-72b9-5880-8ee1-e862748086d5
DOI: 10.1101/055137

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