Article
The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.
PLoS genetics - 1 Jan 2022
Smith Jayson J, Xiao Yutong, Parsan Nithin, Medwig-Kinney Taylor N, Martinez Michael A Q, Moore Frances E Q, Palmisano Nicholas J, Kohrman Abraham Q, Chandhok Delos Reyes Mana, Adikes Rebecca C, Liu Simeiyun, Bracht Sydney A, Zhang Wan, Wen Kailong, Kratsios Paschalis, Matus David Q
Abstract excerpt
Chromatin remodelers such as the SWI/SNF complex coordinate metazoan development through broad regulation of chromatin accessibility and transcription, ensuring normal cell cycle control and cellular differentiation in a lineage-specific and temporally restricted manner. Mutations in genes encoding the structural subunits of chromatin, such as histone subunits, and chromatin regulating factors are associated with...
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