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Article

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease.

Nature - 1 Jun 2025

Rosenberger Florian A, Mädler Sophia C, Thorhauge Katrine Holtz, Steigerwald Sophia, Fromme Malin, Lebedev Mikhail, Weiss Caroline A M, Oeller Marc, Wahle Maria, Metousis Andreas, Zwiebel Maximilian, Schmacke Niklas A, Detlefsen Sönke, Boor Peter, Fabián Ondřej, Fraňková Soňa, Krag Aleksander, Strnad Pavel, Mann Matthias

Abstract excerpt

Protein misfolding diseases, including α1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood1-3. We use spatial proteomics by mass spectrometry and machine learning to map AATD in human liver tissue. Combining Deep Visual Proteomics (DVP) with single-cell analysis4,5, we probe intact patient biopsies to resolve molecular events during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40240610
DOI: 10.1038/s41586-025-08885-4
PMCID: PMC12158776

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TNFSF10

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