Article
The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease
27 Mar 2025
Abstract excerpt
ABSTRACT Cerebral small vessel disease (cSVD) is a significant global health issue, accounting for approximately 25% of ischemic strokes and 20% of all dementia cases. CADASIL, the most common monogenic form of cSVD, is caused by stereotyped mutations in the NOTCH3 receptor that alter the number of cysteine residues in its extracellular domain (Notch3 ECD ). The two hallmark features of CADASIL are the loss of...
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