Article
Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease.
Molecular brain - 19 Mar 2020
Yamamoto Yumi, Kojima Katsutoshi, Taura Daisuke, Sone Masakatsu, Washida Kazuo, Egawa Naohiro, Kondo Takayuki, Minakawa Eiko N, Tsukita Kayoko, Enami Takako, Tomimoto Hidekazu, Mizuno Toshiki, Kalaria Raj N, Inagaki Nobuya, Takahashi Ryosuke, Harada-Shiba Mariko, Ihara Masafumi, Inoue Haruhisa
Abstract excerpt
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTCH3. Our group has previously reported incorporation of NOTCH3 extracellular domain (N3ECD) in the CADASIL-specific granular osmiophilic materials and increase of PDGFRβ immunoreactivity in CADASIL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.