Human germline antibody gene segments encode polyspecific antibodies.

Abstract excerpt

Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to diverse antigens. The binding affinity and specificity for a particular epitope typically increase as antibody genes acquire somatic mutations in antigen-stimulated B cells. In this work, we investigated whether germline gene-encoded antibodies are optimal for polyspecificity by determining the basis for recognition of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Amino Acids
• Share to Computer Simulation