Article
Human germline antibody gene segments encode polyspecific antibodies.
PLoS computational biology - 1 Apr 2013
Willis Jordan R, Briney Bryan S, DeLuca Samuel L, Crowe James E, Meiler Jens
Abstract excerpt
Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to diverse antigens. The binding affinity and specificity for a particular epitope typically increase as antibody genes acquire somatic mutations in antigen-stimulated B cells. In this work, we investigated whether germline gene-encoded antibodies are optimal for polyspecificity by determining the basis for recognition of...
Topics
- Algorithms
- Amino Acids
- Antibodies
- Antigen-Antibody Complex
- Antigens
- Computational Biology
- Computer Simulation
- Epitopes
- Genes, Immunoglobulin
- Humans
- Mutation
- Programming Languages