Article

Comparative Molecular Docking and Toxicity Profiling of Buspirone and Tandospirone Targeting the HTR1A Receptor

2025-11-18

Abstract excerpt

<h4>ABSTRACT</h4> The human serotonin 1A (5-HT1A/HTR1A) receptor is a central target in the treatment of anxiety and mood disorders. However, ligand efficacy is sensitive to receptor conformation. Both Buspirone and Tandospirone are clinically relevant 5-HT1A agonists. This comparative in silico analysis was performed to examine their binding behavior and toxicity profiles. Molecular docking was performed on the...

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Literature Corpus work: d3010af6-f803-533a-a42b-5179ac818a14
DOI: 10.1101/2025.11.17.688977

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