Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.

ACS chemical neuroscience - 21 Sept 2016

Younkin Jason, Gaitonde Supriya A, Ellaithy Amr, Vekariya Rakesh, Baki Lia, Moreno José L, Shah Sneha, Drossopoulos Peter, Hideshima Kelsey S, Eltit Jose Miguel, González-Maeso Javier, Logothetis Diomedes E, Dukat Malgorzata, Glennon Richard A

Abstract excerpt

Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distances might vary, the models are relatively similar in their general construction. Because our preliminary data indicated that two aromatic (hydrophobic) moieties might...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barium
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Receptor, Serotonin, 5-HT2A

Share to Risperidone

Share to Serotonin

Share to Serotonin Antagonists

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 27385190
DOI: 10.1021/acschemneuro.6b00162
PMCID: PMC5333931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.PMID 27385190Read ↗

Comparative Molecular Docking and Toxicity Profiling of Buspirone and Tandospirone Targeting the HTR1A ReceptorSemantic proximity Read ↗

Computational Design of Two New 5-HT <sub>1</sub> B Serotonin Receptor Agonists Derived from NaratriptanSemantic proximity Read ↗

The effect of cancer-associated mutations on ligand binding and receptor function - A case for the 5-HT2C receptor.Semantic proximity Read ↗

Essential role of the C148-C227 disulphide bridge in the human 5-HT2A homodimeric receptor.Semantic proximity Read ↗

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists.Semantic proximity Read ↗

Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists.Semantic proximity Read ↗

In Silico Study Examining New Phenylpropanoids Targets with Antidepressant ActivitySemantic proximity Read ↗

Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptorSemantic proximity Read ↗

5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics.Semantic proximity Read ↗

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.Semantic proximity Read ↗

Design, Synthesis, and Evaluation of Functionalized 5-(4-arylpiperazin-1-yl)-N-Quinolinyl-pentanamides as Selective Dopamine D3 Receptor LigandsSemantic proximity Read ↗

Interactions of granisetron with an agonist-free 5-HT3A receptor model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.