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Article

UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos

24 May 2023

Abstract excerpt

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a protein essential for the maintenance of DNA methylation in somatic cells. However, UHRF1 is predominantly localized in the cytoplasm of mouse oocytes and preimplantation embryos, where it may play a role unrelated to the nuclear function. We herein report that oocyte-specific Uhrf1 KO results in impaired chromosome segregation, abnormal cleavage...

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Identifiers

PMID: 37225425
DOI: 10.26508/lsa.202301904

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