Article
Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice.
Nucleic acids research - 5 Feb 2026
Gao Huihui, Yang Shiyu, Ning Ao, Yin Lisha, Lan Yifei, Cheng Keren, Xiong Wenjing, Xiong Xinxin, Zhang Jin, Chen Jingshou, Feng Shenglei, Fan Xu, Liu Kuan, Gui Yiqian, Zhang Peng, Wang Xiaoli, Wang Fengli, Chen Xiaoxu, Zhang Qinghua, Yuan Shuiqiao
Abstract excerpt
The process of male germ cell development is a central determinant of spermatogenesis. Nevertheless, the genetic regulatory mechanisms underlying male germ cell development in mammals remain largely unclear. In this study, employing a germ cell-specific Hnrnpk knockout mouse model combined with multi-omics analyses, we identified hnRNPK as a key factor necessary for maintaining normal development in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.