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Article

Novel variants in MEI1 cause female infertility characterized by early embryonic arrest and implantation failure.

Journal of assisted reproduction and genetics - 1 Feb 2026

Chen Beili, Chai Menghan, Zhu Yutong, Zhang Qiannan, Yang Dandan, Xiong Min, Cao Yunxia, Wei Zhaolian, Li Lin, Zhang Zhiguo, Xu Yuping

Abstract excerpt

PURPOSE: Early embryonic arrest (EEA) and implantation failure are prevalent causes of female infertility, with genetic factors playing a significant role. MEI1 is a crucial gene for meiotic chromosome synapsis and is essential for the formation of double-strand breaks (DSBs) during germ cell meiosis. MEI1 variants contribute to EEA and implantation failure. In this study, we reported newly identified mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41315153
DOI: 10.1007/s10815-025-03748-3
PMCID: PMC12901775

Genes

MEI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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