Article

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development

2024-04-18

Abstract excerpt

<h4>Summary</h4> Alternative mRNA splicing can generate distinct protein isoforms to allow for the differential control of cell processes across cell types. However, alternative splice isoforms that differentially modulate distinct cell division programs have remained elusive. Here, we demonstrate that mammalian germ cells express an alternate mRNA splice isoform for the kinetochore component, DSN1, a subunit of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1ad5703-5dc0-5de0-aafb-c1c8f91ca5c7
DOI: 10.1101/2024.04.17.589883

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo developmentDOI 10.1101/2024.04.17.589883Read

ESRP1-Mediated Alternative Splicing During Oocyte Development is Required for Mouse FertilitySemantic proximity Read

Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1Semantic proximity Read

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo developmentSemantic proximity Read

The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertilitySemantic proximity Read

Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytesSemantic proximity Read

Mitotic chromosome alignment is required for proper nuclear envelope reassemblySemantic proximity Read

Chromosomal instability by mutations in a novel specificity factor of the minor spliceosomeSemantic proximity Read

Equalizing epigenetically imprinted centromeres in early mammalian embryosSemantic proximity Read

Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregationSemantic proximity Read

Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality.Semantic proximity Read

<i>Spd-2</i> Gene Duplication Suggests Cell-Type Specific Assembly Mechanisms of Pericentriolar MaterialSemantic proximity Read

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulationSemantic proximity Read