Article
Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses.
Cell reports - 17 Dec 2019
Muñoz-Moreno Raquel, Martínez-Romero Carles, Blanco-Melo Daniel, Forst Christian V, Nachbagauer Raffael, Benitez Asiel Arturo, Mena Ignacio, Aslam Sadaf, Balasubramaniam Vinod, Lee Ilseob, Panis Maryline, Ayllón Juan, Sachs David, Park Man-Seong, Krammer Florian, tenOever Benjamin R, García-Sastre Adolfo
Abstract excerpt
Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference...
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