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Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicity

13 Dec 2024

Abstract excerpt

Zoonotic influenza A virus (IAV) infections pose a substantial threat to global health. The influenza RNA-dependent RNA polymerase (RdRp) comprises the PB2, PB1, and PA proteins. Of the last four pandemic IAVs, three featured avian-origin PB1 genes. Prior research linked these avian PB1 genes to increased viral fitness when reassorted with human IAV genes. This study evaluated chimeric RdRps with PB1 genes from...

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PMID: 39671482
DOI: 10.1126/sciadv.ads5735

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