Article

An evolutionary approach to identify mammalian adaptive mutations in the avian influenza polymerase complex

2025-10-27

Abstract excerpt

Avian influenza viruses (AIVs) are a global public health risk; human infection is typically associated with high mortality. While the relationship between several mammalian adaptive mutations and host factors have been described, it is unknown whether additional uncharacterised mutations lead to adaptation. Here, we combine phylogenetic analysis and complementary experimental methods to quantify the impact of nov...

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Literature Corpus work: e746d3f1-adb5-55f5-a6c0-f04a474a1ac8
DOI: 10.1101/2025.10.27.684835

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