Article

Decreased inflammatory cytokine production of antigen-specific CD4<sup>+</sup>T cells in NMDA receptor encephalitis

2020-09-18

Abstract excerpt

Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong T cell infiltration into the hippoc...

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Identifiers and source

Literature Corpus work: 51843415-24a7-54dc-a0d5-bc664759d107
DOI: 10.1101/2020.09.15.20193979

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