Article

An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model

2025-04-14

Abstract excerpt

<title>Abstract</title> <p>Background and Objectives Ataxin-1 (ATXN1) is a protein in which expansion of its polyglutamine tract causes the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) via a gain-of-function. Wild type ATXN1 was recently shown to have a protective role in regulating severity of experimental autoimmune encephalomyelitis (EAE), a well-established mouse model for Multiple scleros...

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Literature Corpus work: fd7d1373-3903-541d-b2de-5377ce8a2198
DOI: 10.21203/rs.3.rs-5664390/v1

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