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Frizzled 6 Drives EMT and Stromal Remodeling Downstream of SP1 in Basal-like Pancreatic Cancer

2026-01-01

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, in part due to its rapid progression and early metastasis. To uncover novel drivers of this aggressive behavior, we first analyzed Frizzled receptor expression in human PDAC datasets and identified Frizzled 6 (FZD6) as uniquely predictive of poor clinical outcomes among all ten Frizzled family members. High FZD6 expression correlated with signi...

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Literature Corpus work
d2e851e5-b33a-5acb-9a94-f442c9d60a23
DOI
10.64898/2025.12.31.697213
Open publication

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Frizzled 6 Drives EMT and Stromal Remodeling Downstream of SP1 in Basal-like Pancreatic CancerDOI 10.64898/2025.12.31.697213
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