Article

Combined analysis of chromatin accessibility, promoter interactions and whole genome sequencing solved the missing heritability in gastric cancer

2024-12-02

Abstract excerpt

Missing heritability in hereditary diffuse gastric cancer (HDGC) ranges from 60 to 90%. These HDGC-like families, despite complying with HDGC clinical criteria, lack CDH1 and CTNNA1 actionable germline variants, and are not offered HDGC-targeted life-saving disease prevention measures. Herein, we explored novel HDGC predisposition mechanisms affecting the CDH1 -regulatory network. We called single-nucleotide (SNV)...

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Literature Corpus work: d2dff110-d8d0-5a55-a31c-c775d4c8124c
DOI: 10.1101/2024.11.27.24317972

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