Article
Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing.
European journal of human genetics : EJHG - 1 Nov 2017
Vogelaar Ingrid P, van der Post Rachel S, van Krieken J Han Jm, Spruijt Liesbeth, van Zelst-Stams Wendy Ag, Kets C Marleen, Lubinski Jan, Jakubowska Anna, Teodorczyk Urszula, Aalfs Cora M, van Hest Liselotte P, Pinheiro Hugo, Oliveira Carla, Jhangiani Shalini N, Muzny Donna M, Gibbs Richard A, Lupski James R, de Ligt Joep, Vissers Lisenka E L M, Hoischen Alexander, Gilissen Christian, van de Vorst Maartje, Goeman Jelle J, Schackert Hans K, Ranzani Guglielmina N, Molinaro Valeria, Gómez García Encarna B, Hes Frederik J, Holinski-Feder Elke, Genuardi Maurizio, Ausems Margreet G E M, Sijmons Rolf H, Wagner Anja, van der Kolk Lizet E, Bjørnevoll Inga, Høberg-Vetti Hildegunn, van Kessel Ad Geurts, Kuiper Roland P, Ligtenberg Marjolijn J L, Hoogerbrugge Nicoline
Abstract excerpt
Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type GC to identify novel GC-predisposing candidate...
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