Article
An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.
The Journal of pathology - 1 Mar 2013
Majewski Ian J, Kluijt Irma, Cats Annemieke, Scerri Thomas S, de Jong Daphne, Kluin Roelof J C, Hansford Samantha, Hogervorst Frans B L, Bosma Astrid J, Hofland Ingrid, Winter Marcel, Huntsman David, Jonkers Jos, Bahlo Melanie, Bernards René
Abstract excerpt
Diffuse gastric cancers typically present as late-stage tumours and, as a result, the 5 year survival rate is poor. Some gastric cancers are hereditary and these tend to be of the diffuse type; 30-40% of hereditary diffuse gastric cancers (HDGCs) can be explained by defective germline alleles of E-cadherin (CDH1), but for the remaining families the factors driving susceptibility remain unknown. We had access to a...
Topics
- Aged
- Alleles
- Amino Acid Sequence
- Antigens, CD
- Cadherins
- DNA, Neoplasm
- Exome
- Female
- Gene Library
- Genetic Linkage
- Genetic Predisposition to Disease