Article

Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis

2019-04-23

Abstract excerpt

Aging increases the risk of Alzheimer’s disease (AD). During normal aging synapses decline and β-Amyloid (Aβ) accumulates. An Aβ defective clearance with aging is postulated as responsible for Aβ accumulation, although a role for increased Aβ production with aging can also lead to Aβ accumulation. To test this hypothesis, we established a long-term culture of primary mouse neurons that mimics neuronal aging (lysos...

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Literature Corpus work: d2dca75e-a7d7-5e0c-bbd7-b1bd697c0eb9
DOI: 10.1101/616540

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