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Article

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.

Neurobiology of disease - 1 Nov 2005

Almeida Claudia G, Tampellini Davide, Takahashi Reisuke H, Greengard Paul, Lin Michael T, Snyder Eric M, Gouras Gunnar K

Abstract excerpt

Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which beta-amyloid (Abeta) may affect synapses remains unclear. Since cultured neurons derived from APP mutant transgenic mice secrete elevated levels of Abeta and parallel the subcellular Abeta accumulation seen in vivo, we asked whether alterations in synapses occur in this setting....

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Source

Identifiers

PMID: 16242627
DOI: 10.1016/j.nbd.2005.02.008

Genes

APP
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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