Article

The Implications of Small Stem Cell Niche Sizes and the Distribution of Fitness Effects of New Mutations in Aging and Tumorigenesis

2015-11-24

Abstract excerpt

Somatic tissue evolves over a vertebrate’s lifetime due to the accumulation of mutations in stem cell populations. Mutations may alter cellular fitness and contribute to tumorigenesis or aging. The distribution of mutational effects within somatic cells is not known. Given the unique regulatory regime of somatic cell division we hypothesize that mutational effects in somatic tissue fall into a different framework...

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Literature Corpus work: d2d9648e-2585-551a-acde-52f4f9b3773a
DOI: 10.1101/032813

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