Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Why do stem cells exist?

Environmental and molecular mutagenesis - 1 Jan 1996

Heddle J A, Cosentino L, Dawod G, Swiger R R, Paashuis-Lew Y

Abstract excerpt

Self-renewing tissues have a differentiation hierarchy such that the stem cells are the only permanent residents of the tissue, and it is in these cells that most cancerous mutations arise. The progeny of the stem cells either remain stem cells or enter a transient proliferating cell population t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cell Differentiation
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Models, Biological

Share to Models, Genetic

Share to Mutation

Source

Identifiers

PMID: 8991061
DOI: 10.1002/(SICI)1098-2280(1996)28:4<334::AID-EM6>3.0.CO;2-B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8991061-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Why do stem cells exist?PMID 8991061Read ↗

Effect of stem cell turnover rates on protection against cancer and aging.Semantic proximity Read ↗

Patterns of cell division and the risk of cancer.Semantic proximity Read ↗

Somatic stem cells and the kinetics of mutagenesis and carcinogenesisSemantic proximity Read ↗

The Implications of Small Stem Cell Niche Sizes and the Distribution of Fitness Effects of New Mutations in Aging and TumorigenesisSemantic proximity Read ↗

Stem cell division theory of cancerSemantic proximity Read ↗

The hierarchical model of stem cell genesis explains the man mouse paradox, Peto's paradox, the red cell paradox and Wright's enigma.Semantic proximity Read ↗

Stem cells: the intestinal stem cell as a paradigmSemantic proximity Read ↗

Stem cell kinetics and intestinal cancer.Semantic proximity Read ↗

Intestinal stem cells protect their genome by selective segregation of template DNA strands.Semantic proximity Read ↗

Stochastic elimination of cancer cells.Semantic proximity Read ↗

Formation of Benign Tumours by Stem Cell MisregulationSemantic proximity Read ↗

Formation of benign tumors by stem cell deregulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.