Article

Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance

2024-07-23

Abstract excerpt

<h4>Summary</h4> Bromodomain (BRD)-containing proteins are chemically tractable multi-domain scaffolding molecules involved in acetyl lysine (Kac) signaling. BRD inhibitors have shown promise in clinical oncology, including melanomas; however, their narrow therapeutic windows and issues with resistance in pre-clinical models highlight the need to better understand the functions of and interconnection between BRD-...

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Literature Corpus work: d2d1017e-d6c2-5657-9032-cdb29631a20f
DOI: 10.1101/2024.07.22.604604

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