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Bromodomain inhibitor treatment leads to overexpression of multiple kinases in cancer cells

6 Sept 2024

Abstract excerpt

The bromodomain and extraterminal (BET) family of proteins show altered expression across various cancers. The members of the bromodomain (BRD) family contain epigenetic reader domains that bind to acetylated lysine residues in both histone and non-histone proteins. Since BRD proteins are involved in cancer initiation and progression, therapeutic targeting of these proteins has recently been an area of interest....

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PMID: 39241280
DOI: 10.1016/j.neo.2024.101046

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