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The BET inhibitors JQ1, AZD5153, and I-BET151 co-opt ubiquitin proteasome system components for altering expression of the BRD4 interactome in a human B cell line

2023-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Chemoproteomic analysis of the BET inhibitors, JQ1, AZD5153, and I-BET151, identified an extremely large signature of ubiquitin modified proteins associating in vitro with a recombinant BRD4 N-terminal protein fragment. The identified proteins included those with known functions in BRD4 complexes for transcriptional and epigenetic control (acetylated histones, the MED complex, BAF complex, RNA...

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Literature Corpus work
003d49a6-1a2c-5ccc-aa5e-5f174219104c
DOI
10.1101/2023.11.09.566482
Open publication

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The BET inhibitors JQ1, AZD5153, and I-BET151 co-opt ubiquitin proteasome system components for altering expression of the BRD4 interactome in a human B cell lineDOI 10.1101/2023.11.09.566482
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