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Article

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

2022-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging organs are linked to many age-associated diseases, senotherapeutic strategies are actively sought to eliminate them. Here, a whole-genome CRISPR knockout screen r...

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Literature Corpus work
d2ce18e0-7e20-5b9b-9da5-bf556956f29b
DOI
10.1101/2022.12.18.520921
Open publication

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The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressDOI 10.1101/2022.12.18.520921
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