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From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs

1 Sept 2022

Abstract excerpt

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression. Senescent cells are resistant to apoptosis, and if not eliminated by the immune system they may accumulate and lead to chronic inflammation and tissue dysfunction. Senolytics are drugs that...

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PMID: 36128715
DOI: 10.1098/rsob.220171

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