Article
Senescence Inducers and Senolytics – Pathways and Drugs Targeting Cellular Senescence
2025-01-29
Abstract excerpt
Physiologic aging and insults from the environment lead to DNA damage. In response, cells in any organ will undergo senescence-induced growth arrest to prevent damaged cells from further propagation. This review focuses on senescence pharmacology. First, we describe senescence induction mechanisms and a unique feature of senescent cells, the SASP (senescence-associated secretory phenotype). Signaling pathways that...
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Identifiers and source
- Literature Corpus work
- c143a1c0-022f-5964-b858-ae9f87daf56a
- DOI
- 10.20944/preprints202501.2140.v1