Article
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
2023-01-17
Abstract excerpt
<title>Abstract</title> <p>Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging organs are linked to many age-associated diseases, senotherapeutic strategies are actively sought to eliminate them. Here, a whole-genome CRISPR knockout...
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Identifiers and source
- Literature Corpus work
- 0b1f6aba-aeae-583c-805b-736fe12b10ac
- DOI
- 10.21203/rs.3.rs-2451188/v1