Article
Senotypes define the diverse landscape of senescent cells.
Nature aging - 1 Sept 2026
Schafer Marissa J, Basisty Nathan, Hertzel Ann V, Rindone Alexandra N, Elisseeff Jennifer H, Suryadevara Vidyani, Aliferis Constantin, Robbins Paul D, Niedernhofer Laura J, Miller Karl N, Adams Peter D, Menon Vilas, Phatnani Hemali, Passos Joao F, Schilling Birgit, Melov Simon, Neretti Nicola, Baker Darren J
Abstract excerpt
Cellular senescence was initially defined in vitro as a stable cell-cycle arrest that occurs after repeated replication, but it is now recognized as a heterogeneous state shaped by cell type, species, senescence-inducing stress, tissue microenvironment and time. To organize this complexity, we propose the term 'senotype' to classify senescent cells by their inputs, molecular features and functional effects. We...
Read the complete abstract on PubMedTopics
- Cellular Senescence
- Humans
- Animals
- Aging
- Phenotype