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Article

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

1 Jun 2022

Abstract excerpt

Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction....

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PMID: 35821852
DOI: 10.3389/fragi.2022.828058

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