Article

A mechanical pacemaker sets rhythmic nephron formation in the kidney

2023-11-21

Abstract excerpt

The developing mammalian kidney exponentially duplicates nephron-forming stem cell niches at the tips of the urinary collecting duct tree to achieve massively parallel function. Nephron formation rate has a clinically meaningful effect on person-to-person variability in nephron endowment 1–5 , while exerting in vitro control could enable sustained waves of nephrogenesis in organoid-derived synthetic kidney tissu...

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Literature Corpus work: 6a202832-a6f0-5996-b487-f9b24e1ccc34
DOI: 10.1101/2023.11.21.568157

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