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Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery.

EBioMedicine - 1 Jul 2018

Benedetti Valentina, Brizi Valerio, Guida Patrizia, Tomasoni Susanna, Ciampi Osele, Angeli Elena, Valbusa Ugo, Benigni Ariela, Remuzzi Giuseppe, Xinaris Christodoulos

Abstract excerpt

The lack of engineering systems able to faithfully reproduce complex kidney structures in vitro has made it difficult to efficiently model kidney diseases and development. Using polydimethylsiloxane (PDMS) scaffolds and a kidney-derived cell line we developed a system to rapidly engineer custom-made 3D tubules with typical renal epithelial properties. This system was successfully employed to engineer...

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Identifiers

PMID: 30049385
DOI: 10.1016/j.ebiom.2018.06.005
PMCID: PMC6085557

Genes

PAX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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