Article
Repertoire and evolution of miRNA genes in four divergent nematode species.
Genome research - 1 Nov 2009
de Wit Elzo, Linsen Sam E V, Cuppen Edwin, Berezikov Eugene
Abstract excerpt
miRNAs are approximately 22-nt RNA molecules that play important roles in post-transcriptional regulation. We have performed small RNA sequencing in the nematodes Caenorhabditis elegans, C. briggsae, C. remanei, and Pristionchus pacificus, which have diverged up to 400 million years ago, to establish the repertoire and evolutionary dynamics of miRNAs in these species. In addition to previously known miRNA genes...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Caenorhabditis
- Caenorhabditis elegans
- Conserved Sequence
- Evolution, Molecular
- Gene Library
- Genes, Helminth
- Genetic Variation
- MicroRNAs