Article

KRAS, APC, and TP53 mutations define opposing immune archetypes in stage III colorectal cancer

2025-11-12

Abstract excerpt

<title>Abstract</title> <p> Colorectal cancer (CRC) exhibits marked genomic and immune heterogeneity; stage III CRC remains prone to recurrence and metastasis despite standard therapy. To delineate genotype–immune relationships, we integrated whole-exome sequencing and transcriptomic profiling in 69 Thai patients with stage III CRC. We investigated the top 3 somatic mutations and their effects on the tumor immun...

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Literature Corpus work: 561de095-55e8-5e73-ac30-b4cf5d1370b0
DOI: 10.21203/rs.3.rs-7903094/v1

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